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Cachexia in Aging and Cancer Conference
December 04, 2004
 A significant proportion of elderly people, as well as a majority of patients with advanced cancer, experience a syndrome of wasting known as cachexia anorexia. The resulting emaciation and functional loss remain hallmarks of advanced old age and of neoplastic disease. The purpose of this conference is to assess the needs, gaps and opportunities for basic and clinical research on the cachexia-anorexia syndrome of cancer and aging. This year's conference will have a special focus on skeletal muscle atrophy and on the inflammatory and proteolytic processes that underlie it. Speakers and titles are listed below.
The Conference will be held on DECEMBER 4TH and 5TH, 2004 Chicago Hyatt at McCormick Place in Chicago, Illinois, USA Scientific Program Committee Sponsors Par Pharmaceutical Inc Amgen 
Program December 4, 2004 | Session 1. The role of catabolic, pro-inflammatory factors in wasting skeletal muscle catabolism | | 8:00 | Deans, Chris | Systemic inflammation, cachexia and prognosis in patients with cancer. | | 8:30 | Schuster, Michael W | Cytokine-induced anorexia | | 9:00 | Rall, L | Cytokines and Sarcopenia | | 9:30 | Lang, Charles H | Muscle as a Component of the Innate Immune System: Inflammation-Induced Upregulation of Muscle Cytokines | | 10:00 | Break | | | 10:30 | Eagle, Craig | Inhibition of cyclooxygenase-2 by celecoxib reverses tumor-induced wasting | | 11:00 | Trikha, Mohit | Potential use of monoclonal antibodies: pitfalls and benefits | | 11:30 | Moldawer, Lyle L | Why are cytokines important and what is their true metabolic role? | | 12:00 Lunch / poster discussion | | Session 2. Mechanisms of muscle wasting proteolysis | | 1:30 | Tisdale, Michael J | Mechanism of the induction of skeletal muscle atrophy by angiotensin I/II | | 2:00 | Du, Jie | Cellular Mechanisms of Muscle Proteolysis Include Activation of Caspase-3 and the Ubiquitin-proteasome System | | 2:30 | Attaix, Didier | Alterations in skeletal muscle proteolysis in aging | | 3:00 | Break | | | 3:30 | Han, HQ | Regulation of Protein Catabolism by novel ubiquitin ligase E3-II During Cancer Cachexia | | 4:00 | Hasselgren, Per-Olof | Calpain and calpastatin in muscle wasting during sepsis | | 4:30 | Muscaritoli, Maurizio | Evidence from Cachectic Human Muscle | | 5:00 | Plenary Lecture:
Goldberg, Alfred L | Functions of the Proteasome: From Protein Breakdown and Immune Surveillance to Cancer Therapy and Cachexia |
December 5, 2004
| | Session 3. Anorexia of cancer and aging | | 8:00 | Morley, John | Pathophysiology of Anorexia in the Elderly | | 8:30 | Meguid, Michael M | Anorexia of Cancer | | 9:00 | Wilson, Margaret-Mary G. | The CNAQ questionnaire: A way to predict future weight loss | | 9:30 | Break | | | Session 4. Current methodology and technology in cachexia research | | 10:00 | Baumgartner, Richard N | Diagnosis and Epidemiology of Sarcopenia and Sarcopenic-Obesity | | 10:30 | Carter, Christy | Muscle strength and aging: measurement in animal models | | 11:00 | Heymsfield, Steven B | Imaging technology in the assessment of skeletal muscles and adipose tissue | | 11:30 | Wolfe, Robert R | Assessment of Amino acid requirements to maximize muscle protein anabolism | | 12:00 Lunch and poster discussion | | Session 5. Clinical anti-cachexia therapy. | | 1:30 | Evans, William | Exercise and its counter cachexia effect on muscle and whole body protein metabolism in old and underweight subjects | | 2:00 | Urban, Randy J | Anabolic effects of testosterone in older men | | 2:30 | Anker, Stefan, D. | Prognostic importance of weight loss in chronic heart failure and treatment with ACE-inhibitors | | 3:00 | Fearon, Kenneth | A critical assessment of the outcome measures and goals of intervention in cancer cachexia | | 3:30 | Break | | | 4:00 | Bruera, Eduardo | A critical evaluation of the successes and failures in clinical cancer cachexia treatment. | | 4:30 | Yeh, Shing Shing | Drug therapy and weight loss in older persons | | 5:00 | Jones, Lee | Exercise therapy for patients with cancer |
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