Experimental Oncology

Xuejun Sun

Faculty Services Officer IV
Experimental Oncology
Department of Oncology
University of Alberta
Cross Cancer Institute
11560 University Avenue
Edmonton, Alberta T6G 1Z2
Tel: 780.432.8898


Cell Imaging
My primary duty in the department of Oncology is ensuring the smooth operation of the Cell Imaging Facility. However, I have several collaborations with others investigators at CCI and outside of CCI related to Cancer biology and Cell biology using imaging based technologies.
Research Interests
I am generally interested in imaging of cellular processes/activities and application of advanced imaging technologies to cell/cancer biology.




Selected Publications:

Knoblach B, Sun X, Coquelle N, Fagarasanu A, Poirier RL, Rachubinski RA (2013) An ER-peroxisome tether exerts peroxisome population control in yeast.  EMBO J.  2013 Sep 11; 32(18):2439-53. doi: 10.1038/emboj.2013.170. Epub 2013 Jul 30.
Lee S, Park YY, Kim SH, Nguyen OT, Yoo YS, Chan GK, Sun X, Cho H. (2013) Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition. Cell Mol Life Sci. 2013 Aug 2. [Epub ahead of print] PMID: 23907611
Wang H, Wei E, Quiroga AD, Sun XJ, Touret N, Lehner R.(2010) Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression. Mol Biol Cell. 21(12):1991-2000. Epub 2010 Apr 21.
Damaraju S, Zhang N, Li N, Tao L, Damaraju VL, Dufour J, Santos C, Sun XJ, Mackey J, Wishart DS, Cass CE, Li L. (2010) Evidence for Co-enrichment of Micronuclei in Plasma Membrane Preparations Based on Proteomic Profiles from Breast Cancer Cell lines (MN1 and MDD2) Differing in p53 Status. Anal Biochem. 396(1):69-75.
Roa W, Zhang X, Guo L, Shaw A, Hu X, Xiong Y, Gulavita S, Patel S, Sun XJ, Chen J, Moore R, Xing JZ. (2009) Gold nanoparticles sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle. Nanotechnology. 20(37):375101. Epub 2009 Aug 26.PMID: 19706948
JK. Famulski, L. Vos, XJ Sun and G Chan (2008) Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. The Journal of Cell Biology, 180(3) 507–520
M. He, Y. Zeng, X.J. Sun and D.J. Harrison (2008) Confinement effects on the morphology of photopatterned porous polymer monoliths for capillary and microchip electrophoresis of proteins. Electrophoresis 2008, 29, 2980–2986
KG, Sun X, Meinertzhagen IA, Nassel DR (2008) Glutamate, GABA and Acetylcholine Signaling Components in the Lamina of the Drosophila Visual System. PLoS ONE 3(5): e2110. doi:10.1371/journal.pone.0002110 
Shen Q, Rah JJ, Zhang J, Gunasekera N, Sun X, Shaw AR, Hendzel MJ, Hoffman P, Bernier A, Hugh JC. (2008) MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1. Mol Cancer Res. 2008 6(4):555-67. PMID: 18403635
Mita R, Coles, JE., Glubrecht DD, Sung R, Sun XJ, Godbout R (2007) B-FABP-expressing radial glial cells: The malignant glioma cell of origin? NEOPLASIA 9 (9): 734-U47 SEP 2007 
SM Lee; SJ Kim; XJ Sun; JH Lee and HS Cho (2007) Cell Cycle-dependent Mitochondrial Biogenesis and Dynamics in Mammalian Cells. Biochemical and Biophysical Research Communications. 357 (1): 111-117.
VL Damaraju, AN Elwi, C Hunter, P Carpenter, C Santos, GM Barron, XJ Sun, SA Baldwin, JD Young, JR Mackey, MB Sawyer and CE Cass, (2007) Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney J. Physiol, Renal Physiology, 293 (1): F200-F211 JUL 2007 
X Tao, H Chen, XJ Sun, JF Chen and WH. Roa (2007) Formulation and cytotoxicity of doxorubicin loaded in self-assembled bio-polyelectrolyte microshells. International Journal of Pharmaceutics 336 (2007) 376–381
Zhang J, Sun XJ, Smith KM, Carpenter P., Barron G., Peng YS, Robins MJ, Baldwin SA, Young JD, and Cass CE. (2006) Studies of Nucleoside Transporters Using Autofluorescent Nucleoside Analogues. Biochemistry 45(4):1087-98. 
Li L, K Roy, S Bléoo, S Katyal, XJ Sun, and RB Godbout (2006) Convergence of DDX1 foci, cleavage bodies, Cajal bodies and gems during the S phase of the cell cycle. Mol Biol Cell. 17(3):1126-40.
Zhang J, KM. Smith, T. Tackaberry , XJ Sun, MD Slugoski, MJ Robins, LPC Nielsen, I Nowak, SA Baldwin, JD Young, and CE. Cass (2006) Characterization of Uridine Permease, FUI1, of Saccharomyces cerevisiae: the transport mechanism and permeant-binding motif. J Biol Chem. 281(38):28210-28221. 
Tao X., XJ Sun, JM Su, JF, Chen and W. Roa (2006) Natural microshells of alginate-chitosan: Unexpected stability and permeability. Polymer 47:6167-6171.
Shen SW, J. Lee, XJ. Sun, HL Wang, M. Weinfeld, X.C. Le (2006) Elevation of Cellular BPDE Uptake by Human Cells: A Possible Factor Contributing to Co-carcinogenicity by Arsenite Environmental Health Perspective, 2006 Aug. 18; [Epub ahead of print]. 
Roa W, Chen H, Gulavati S, Th’ng J, Sun XJ, Petruk K, Moore R., (2005) Enhancement of Radiation Sensitivity with BH3I-1 in Non-small Cell Lung Cancer. Clin Invest. Med. 28(2):55-63.
Xing JZ, Zhu L, Jackson JA, Gabos S, Sun XJ, Wang XB, Xu X. (2005) Dynamic monitoring of cytotoxicity on microelectronic sensors. Chem. Res. Toxicol. 18(2):154-61. 
Mei N, Lee J., Sun XJ, Xing JZ, Janson J., Le XC, Weinfeld M., (2003) Genetic predisposition to the cytotoxicity of arsenic: the role of DNA damage and ATM, FASEB J. 17(15):2310-2.
Maxwell CA, Keats JJ, Crainie M, Sun Xj, Yen T, Shibuya E, Hendzel M, Chan G, Pilarski LM (2003) RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol Biol Cell. 14(6):2262-76.
Everett H., Barry M., Sun XJ, Lee SF, Frantz C, Berthiaume LG., McFadden G. and Bleackley RC. (2002) The Myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. J. Exp. Med. 196(9):1127-1140.
Bléoo S., Sun XJ., Hendzel MJ., Rowe JM., Packer M. and Godbout R. (2001) Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-mRNA. Mol. Biol. Cell. 12:3046-3059.
Lever M.A., Th’ng JPH., Sun, XJ and Hendzel MJ (2000) GFP-labeled Histone H1.1 exhibits dynamic exchange in chromatin in live cells. Nature 408(6814): 873 - 876.
Meinertzhagen IA., Piper ST., Sun XJ. and Fröhlich A. (2000). Neurite morphogenesis of identified visual interneurons and its relationship to photoreceptor synaptogenesis in the flies, Musca domestica and Drosophila melanogaster. Europ. J. Neurosci. 12(4):1342-56.
Everet H, Barry M, Lee SF, Sun XJ, Graham K, Stone J, Bleackley RC, and McFadden G (2000) M11L: An novel mitochondria –localized protein of myxoma virus that blocks apoptosis of infected leukocytes J. Exp. Med. 191(9):1497-98.
Spencer CA, Kruhlak MJ, Jenkins HL, Sun XJ, Bazett-Jones DP. (2000) Mitotic transcription repression in vivo in the absence of nucleosomal chromatin condensation. J Cell Biol. 150(1):13-26.